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Live blog update| Beirut explosion

One American citizen killed in blast: US State Department

One US citizen was killed and several others were injured in the blast in Beirut, a State Department spokesperson told CNN.

"All US Chief of Mission personnel in Beirut are safe and accounted for and US Embassy Beirut is open," the spokesperson said on Wednesday.

"We offer our sincerest condolences to their loved ones and are working to provide the affected US citizens and their families all possible consular assistance," the spokesperson said.

"We are working closely with local authorities to determine if any additional US citizens were affected. Out of respect for the families at this difficult time, we have no further comment."